Impact of Exclusive Breastfeeding on Vitamin D Status in Children Under Five in Karachi

Breastfeeding and Vitamin D Status in Karachi Children

Authors

DOI:

https://doi.org/10.62807/jowach.v2i1.2025.6-11

Keywords:

Vitamin D deficiency, exclusive breastfeeding, children, public health, nutrition

Abstract

Background:
Vitamin D deficiency poses a significant public health challenge, particularly for young children. While breastfeeding provides essential nutrients, its influence on vitamin D status in children remains unclear, especially in populations with high deficiency rates. This study evaluates the impact of exclusive breastfeeding on the vitamin D status of children under five in Karachi, Pakistan.

Methods:
This retrospective cross-sectional study included 400 children aged 0 to 5 years who underwent vitamin D testing at a diagnostic laboratory in Karachi in 2022. The study utilized logistic regression and multivariate analyses to examine the relationship between exclusive breastfeeding and vitamin D status, accounting for potential confounders.

Results:
The prevalence of vitamin D deficiency was 71.8%. Children exclusively breastfed for ≥6 months had a significantly lower risk of deficiency (OR: 0.60, 95% CI: 0.45-0.80, p < 0.001). Multivariate analysis confirmed that exclusive breastfeeding independently contributed to a reduced risk of deficiency, alongside age and seasonal factors.

Conclusions:
Promoting exclusive breastfeeding, coupled with safe sun exposure and dietary education, could reduce vitamin D deficiency in young children in Karachi. Public health strategies should integrate these findings to enhance childhood nutrition and health outcomes.

Author Biography

Syeda Huda Zehra Jaffri, Shaheed Zulfikar Ali Bhutto Institute of Science and Technology, Karachi, Pakistan

Shaheed Zulfikar Ali Bhutto Institute of Science and Technology, Karachi, Pakistan (MBBS, MSPH)

References

Chemes V. , Аbrahamovych О. , Abrahamovych U. , Ivanochko R. , & Kobak L.. Calcium-phosphorus metabolism and markers of its regulation in patients with rheumatoid arthritis with violation of bone mineral density: character and diagnostic value. Lviv Clinical Bulletin 2023;3-4(39-40):76-82. https://doi.org/10.25040/lkv2022.03-04.076

Saadon H.. Vitamin d deficiency in childhood: a review. University of Thi-Qar Journal of Science 2024;11(1):176-184. https://doi.org/10.32792/utq/utjsci/v11i1.1230

Tabassum A. , Ali A. , Zahedi F. , & Ismail N.. Immunomodulatory role of vitamin d on gut microbiome in children. Biomedicines 2023;11(5):1441. https://doi.org/10.3390/biomedicines11051441

Sánchez‐Zuno G. , González‐Estevez G. , Matuz-Flores M. , Macedo‐Ojeda G. , Hernández‐Bello J. , Mora J. et al.. Vitamin d levels in covid-19 outpatients from western mexico: clinical correlation and effect of its supplementation. Journal of Clinical Medicine 2021;10(11):2378. https://doi.org/10.3390/jcm10112378

Jordan T. , Siuka D. , Rotovnik N. , & Pfeifer M.. Covid-19 and vitamin d– a systematic review. Slovenian Journal of Public Health 2022;61(2):124-132. https://doi.org/10.2478/sjph-2022-0017

Al‐Hussaini A. , Alshehry Z. , Al-Dehaimi A. , & Bashir M.. Vitamin d and iron deficiencies among saudi children and adolescents. Saudi Journal of Gastroenterology 2022;28(2):157-164. https://doi.org/10.4103/sjg.sjg_298_21

Al‐Hussaini A. , Alshehry Z. , Al-Dehaimi A. , & Bashir M.. Vitamin d and iron deficiencies among saudi children and adolescents. Saudi Journal of Gastroenterology 2022;28(2):157-164. https://doi.org/10.4103/sjg.sjg_298_21

Cui A. , Zhang T. , Xiao P. , Fan Z. , Wang H. , & Zhuang Y.. Global and regional prevalence of vitamin d deficiency in population-based studies from 2000 to 2022: a pooled analysis of 7.9 million participants. Frontiers in Nutrition 2023;10. https://doi.org/10.3389/fnut.2023.1070808

Jiang Z. , Pu R. , Li N. , Chao-zhen C. , Li J. , Dai W. et al.. High prevalence of vitamin d deficiency in asia: a systematic review and meta-analysis. Critical Reviews in Food Science and Nutrition 2021;63(19):3602-3611. https://doi.org/10.1080/10408398.2021.1990850

Martens P. , Gysemans C. , Verstuyf A. , & Mathieu C.. Vitamin d’s effect on immune function. Nutrients 2020;12(5):1248. https://doi.org/10.3390/nu12051248

Chakhtoura M. , Rahme M. , Chamoun N. , & Fuleihan G.. Vitamin d in the middle east and north africa. Bone Reports 2018;8:135-146. https://doi.org/10.1016/j.bonr.2018.03.004

Webb A. , Kazantzidis A. , Kift R. , Farrar M. , Wilkinson J. , & Rhodes L.. Colour counts: sunlight and skin type as drivers of vitamin d deficiency at uk latitudes. Nutrients 2018;10(4):457. https://doi.org/10.3390/nu10040457

Pligt P. , Willcox J. , Szymlek‐Gay E. , Murray E. , Worsley A. , & Daly R.. Associations of maternal vitamin d deficiency with pregnancy and neonatal complications in developing countries: a systematic review. Nutrients 2018;10(5):640. https://doi.org/10.3390/nu10050640

Poh B. , Wong J. , Lee S. , Chia J. , Yeo G. , Sharif R. et al.. Triple burden of malnutrition among malaysian children aged 6 months to 12 years: current findings from seanuts ii malaysia. Public Health Nutrition 2023;27(1). https://doi.org/10.1017/s1368980023002239

Isa H. , Almaliki M. , Alsabea A. , & Mohamed A.. Vitamin d deficiency in healthy children in bahrain: do gender and age matter?. Eastern Mediterranean Health Journal 2020;26(3):260-267. https://doi.org/10.26719/emhj.19.084

Hribar M. , Žlavs K. , Pravst I. , & Žmitek K.. Validation of the food frequency questionnaire for the assessment of dietary vitamin d intake. Frontiers in Nutrition 2022;9. https://doi.org/10.3389/fnut.2022.950874

Arshad S. and Zaidi S.. Vitamin d levels among children, adolescents, adults, and elders in pakistani population: a cross-sectional study. BMC Public Health 2022;22(1). https://doi.org/10.1186/s12889-022-14526-6

Kapoor A. , Fatima F. , Naveed A. , Shaikh G. , Solangi D. , & Shanker B.. Vitamin d deficiency among well nourished and malnourished children of school going age at district tharparkar. Pakistan Journal of Medical and Health Sciences 2022;16(7):873-875. https://doi.org/10.53350/pjmhs22167873

Közler S. and Şaylı T.. Factors influencing initiation and discontinuation of vitamin d supplementation among infants. 2024. https://doi.org/10.22541/au.170666449.95013996/v1

Dawodu A. , Salameh K. , Al-Janahi N. , Bener A. , & Elkum N.. The effect of high-dose postpartum maternal vitamin d supplementation alone compared with maternal plus infant vitamin d supplementation in breastfeeding infants in a high-risk population. a randomized controlled trial. Nutrients 2019;11(7):1632. https://doi.org/10.3390/nu11071632

Tung K. , Wong R. , Tsang H. , Chan B. , Wong S. , So H. et al.. An assessment of risk factors for insufficient levels of vitamin d during early infancy. Nutrients 2021;13(4):1068. https://doi.org/10.3390/nu13041068

Heo JS, Ahn YM, Kim AE, Shin SM. Breastfeeding and vitamin D. Clin Exp Pediatr. 2022;65(9):418–429. https://doi.org/10.3345/cep.2021.00444

Durá-Travé T, Gallinas-Victoriano F. Pregnancy, breastfeeding, and vitamin D. Int J Mol Sci. 2023;24(15):11881. https://doi.org/10.3390/ijms241511881

Kazemain E, Ansari S, Davoodi SH, Patterson WB, Shakerinava P, Wagner CL, Amouzegar A. The effect of maternal vitamin D supplementation on vitamin D status of exclusively breastfeeding mothers and their nursing infants: A systematic review and meta-analysis of randomized clinical trials. Adv Nutr. 2022;13(2):568-585. Available from: https://doi.org/10.1093/advances/nmab126

M S. Study of vitamin D levels in exclusively breastfed term infants in a tertiary care centre. Int J Contemp Pediatr. 2017;5(1):71-74. Available from: https://doi.org/10.18203/2349-3291.ijcp20175425

DePender S, Russell MM, DeJager J, Comstock SS. Impact of maternal vitamin D supplementation during breastfeeding on infant serum vitamin D levels: A narrative review of the recent evidence. Children. 2022;9(12):1863. Available from: https://doi.org/10.3390/children9121863

Tan ML, Abrams SA, Osborn DA. Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health. Cochrane Database Syst Rev. 2020;(12):CD013046. Available from: https://doi.org/10.1002/14651858.CD013046.pub2

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Published

31-03-2025

How to Cite

Jaffri, S. H. Z. (2025). Impact of Exclusive Breastfeeding on Vitamin D Status in Children Under Five in Karachi: Breastfeeding and Vitamin D Status in Karachi Children. Journal of Women and Child Health, 2(1), 6–11. https://doi.org/10.62807/jowach.v2i1.2025.6-11

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